Determination of Melatonin in Compound Melatonin Capsules by UV-spectrophotometry / 中国药房

OBJECTIVE:To establish UV-spectrophotometry method for the determination of melatonin in the compound melatonin capsules.METHODS:The UV-spectrophotometry was adopted with the detection wavelength at277nm.RESUL_ TS:There was a good linear relationship between melatonin and its absorbability(r=0.9996)within the concentration range of5～25?g/ml.The average recovery was96.49%(RSD=1.21%,n=6).CONCLUSION:The method is accurate,reliable,convenient and stable.